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KMID : 0356619950100040418
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Journal of Korean Society of Endocrinology
1995 Volume.10 No. 4 p.418 ~ p.423
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A Case of Polyglandular Autoimmune Syndrome
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정의태
박재홍/김도형/정병오/고경수/이병두
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Abstract
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The polyglandular autoimmune syndrome designates the dysfunction of endocrine and nonendocrine system involving two or more organs on the basis of an autoimmune mechanism. The autoimmune nature of these diseases has been based on the presence of
lymphocytic infiltration in the affected gland, organ specific autoantibodies in the serum, cellular immune defect and association with the HLA DR/DQ genes or immune response genes. This syndrome is usually classified into three classes and their
etiology or pathogenesis is still not completely understood.
A 28-year-old woman developed vitiligo and insulin dependent diabetes mellitus during the treatment of Graves' disease with antithyroid drug. She had a tendency of spontaneous ketonemia and serum c-peptide levels were low(0.21, 0.16ng/mL: fasting
and
glucagon stimulated). Thyrotrophin binding inhibitor immunoglobulinand pancreas iIslet cell cytoplasmic antibody were positive. We report here a case of polyglandular autoimmune syndrome. Type III manifesting Graves' disease, vitiligo, and
insulin
dependent diabetes mellitus(J Kor Soc Endoerinol 10:418~423, 1995).
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KEYWORD
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